Personalized Medicine: Identifying & Addressing The Root Cause of Disease

This is the first lecture inside our brand-new program, Personalized Medicine: Identifying & Addressing the Root Cause of Disease. Together, we will explore a revolutionary new approach to uncovering the underlying factors that dictate chronic disease.

The Personalized Medicine program curriculum is divided into seven comprehensive courses that systematically examine the specifics of each core biological process and the core modulators we can use to influence health and disease. 

Our program will teach you how to uncover, identify, and address the root causes of chronic disease, empowering you to deliver personalized, targeted, and holistic care.

By the end of the program, you will learn to:

  • Understand and identify the core biochemical mechanisms driving chronic disease.
  • Connect your patient’s signs, symptoms, and laboratory results directly to specific biochemical dysfunctions.
  • Detect subtle clinical clues—signs, symptoms, and laboratory findings—that reveal underlying upstream mechanisms.
  • Interpret advanced laboratory tests to gain deeper clinical insights into your patient’s health.
  • Design personalized nutrition and lifestyle interventions to modulate your patient’s underlying cellular dysfunction.
  • Strategically incorporate supplements and nutraceuticals to support and improve health.
  • Evaluate the latest research to explore novel approaches for current pharmaceutical options.

We’ll break down the underlying mechanisms so you can understand why one strategy might benefit one person yet be ineffective or even harmful to another. 

Each module will directly connect your patient’s signs, symptoms, and laboratory results to specific biochemical dysfunctions. You’ll learn how to strategically modify the core modulators of health and disease to address your patient’s underlying cellular dysfunction. 

Join us as we redefine what it means to be healthy.

The Curriculum

The Personalized Medicine program curriculum is divided into seven comprehensive courses. Enroll during our early-bird promotion, and you will gain access to all seven courses as they’re released at no additional charge! The entire program is self-paced, with access to a members-only group chat should any questions arise.

  • Module 1: A New Paradigm for Health and Disease
  • Module 2: Systems biology, systems medicine, and network medicine
  • Module 3: Rethinking disease classifications
  • Module 4: Key principles in molecular biology
  • Module 5: Foundations in metabolism
  • Module 6: Foundations in immunology
  • Module 7: Foundations in genetics and epigenetics
  • Module 8: The limbic system
  • Module 9: Multi-omics
  • Module 10: Hallmarks of aging
  • Module 11: How to think through every evaluation
  • Module 12: Frameworks and strategies for evaluating and managing vague and nonspecific symptoms

  • Module 1: Gastrointestinal Function
    1. Digestion, absorption, and the GI tract
    2. Introduction to the microbiome
    3. Microbial metabolites & postbiotics
    4. Microbiota cross-talk
      • The brain, liver, immune system, and mitochondria
    5. Intestinal permeability
    6. Gut-associated lymphoid tissue
    7. Metabolic endotoxemia (lipopolysaccharides)
    8. Comprehensive stool analysis testing
  • Module 2: Macronutrients
    1. Protein function, classification, and structure
    2. Protein digestion and absorption
    3. Lipid function, classification, and structure
    4. Lipid digestion and absorption
    5. Carbohydrate function, classification, and structure
    6. Carbohydrate digestion and absorption
  • Module 3: Amino Acids
    1. Amino acid function, classification, and structure
    2. Transamination
    3. Amidation
    4. Deamination
    5. Urea cycle
    6. Plasma amino acid testing
  • Module 4: Lipids
    1. Fatty acid function, classification, and structure
    2. Triglycerides
    3. Phospholipids
    4. Cholesterol
    5. Lipogenesis
    6. Lipolysis
    7. Fatty acids
    8. Beta-oxidation
    9. Ketogenesis
    10. Ketolysis
    11. Fatty acid profile testing
    12. Carnitine and acylcarnitine profile testing
  • Module 5: Monosaccharides
    1. Monosaccharide function, classification, and structure
    2. Galactose
    3. Fructose
    4. Glucose
    5. Glucose transporters
    6. Gluconeogenesis
    7. Glycogenesis
    8. Glycogenolysis
    9. Glycolysis (aerobic vs anaerobic)
    10. Warburg effect
    11. Pentose phosphate pathway
    12. Ketone (beta-hydroxybutyrate and acetoacetate) testing
    13. Lactate and pyruvate testing
  • Module 6: Micronutrients
    1. Vitamins
    2. Minerals
    3. Phytonutrients
    4. Nucleotides
  • Module 7: Micronutrient Deficiencies
    1. Dietary reference intake vs optimal health
    2. Subclinical (asymptomatic) vs clinical (symptomatic) deficiencies
    3. Cofactors, substrates, and enzymes
    4. Triage theory
    5. Nutrient interactions and antagonisms
    6. Problems with conventional lab testing
    7. Functional biomarkers
    8. Cellular nutrition assays
    9. Urine organic acid testing
  • Module 8: The Physical Exam
    1. Micronutrients
    2. Macronutrients
  • Module 9: Personalized Nutrition
    1. Nutrigenomics and nutrigenetics
    2. Nutrition and metabolism
    3. Nutrition and immune function
    4. Therapeutic diets
  • Module 10: Supplements and Nutraceuticals
    1. Antioxidants
    2. Fiber, prebiotics, and probiotics
    3. Protein and amino acids
    4. Omega fatty acids (3,6, 7, and 9)
    5. Medium-chain fatty acids
    6. Ketones
    7. Adaptogens
    8. Botanicals
  • Module 11: Disease Spotlight
    1. Rethinking Fatty liver Beyond Conventional Understanding
    2. Rethinking Asthma beyond Conventional Understanding
    3. Rethinking Hyperlipidemia and Atherosclerosis Beyond Conventional Understanding

  • Module 1: The central role of mitochondria
  • Module 2: Mitochondria DNA and epigenetics
  • Module 4: Mitochondrial biogenesis, fission, fusion, and mitophagy
  • Module 5: Citric acid cycle
  • Module 6: Oxidative phosphorylation
  • Module 7: Metabolic Flexibility
  • Module 8: Redox
    1. Oxidative stress
    2. Antioxidants vs. pro-oxidants
    3. Signaling molecules
    4. Cellular senescence
  • Module 9: Catabolism vs anabolism
    1. Feeding and fasting
    2. Calorie restriction and overnutrition
    3. MTOR and AMPK
    4. Insulin and IGF-1
    5. Autophagy and mitophagy
    6. Therapeutic diet for mitochondrial health
  • Module 10: Counter-regulatory hormones
    1. Glucagon
    2. Epinephrine
    3. Cortisol
    4. Growth hormone
  • Module 11: Mitochondria in Chronic Disease
    1. The cell danger response and healing cycle
    2. The clinical presentation
    3. Mitochondria and gut-microbiome cross-talk
    4. Mitochondria and the immune system
    5. Mitochondria and metabolic disease
    6. Mitochondria and neurodegenerative disease
  • Module 12: Testing for metabolic and mitochondrial dysfunction
  • Module 13: Personalized interventions to improve metabolic and mitochondrial health
  • Module 14: Disease Spotlight
    1. Rethinking Cancer Beyond Conventional Understanding
    2. Rethinking Alzheimers Beyond Conventional Understanding
    3. Rethinking Autism Beyond Conventional Understanding

  • Module 1: Importance of exercise in healthspan and longevity
  • Module 2: Adipose tissue
  • Module 3: Muscle mass
  • Module 4: Weight loss
  • Module 5: Satiety signals
    1. Adiponectin
    2. Ghrelin
    3. Leptin
    4. GLP-1
    5. Cholecystokinin
    6. Peptide YY
  • Module 6: Exercise and metabolic disease
  • Module 7: Exercise and mitochondrial health
  • Module 8: Exercise and genetics
  • Module 9: Exercise and immune function
  • Module 10: Exercise nutrition for performance, recovery, and repair
  • Module 11: Personalized exercise programs
  • Module 12: Disease Spotlight
    1. Rethinking Aging Beyond Conventional Understanding
    2. Rethinking Insulin Resistance, Metabolic Syndrome, and Diabetes Beyond Conventional Understanding

  • Module 1: Components of the immune system
  • Module 2: Acute infection and inflammation
  • Module 3: Revisiting the gut-immune axis
  • Module 4: Chronic inflammation
  • Module 5: Immune tolerance and immune dysfunction
  • Module 6: Food allergy (IgE) vs. food sensitivity (IgG)
  • Module 7: Chronic infection and inflammation
    1. Cytokines and chemokines
    2. Reactive oxygen and nitrogen species
    3. Complement system
    4. Pattern recognition receptors
    5. Inflammasomes
    6. Transcription factors
  • Module 8: Immune function and chronic disease
    1. Patient presentation and the physical exam
    2. Lab testing and interpretation
  • Module 9: Immunomodulators
  • Module 10: Disease Spotlight
    1. Rethinking Autoimmune Disease Beyond Conventional Understanding
    2. Rethinking Osteoarthritis Disease Beyond Conventional Understanding

  • Module 1: Homeostasis, allostasis, and hormesis
  • Module 2: Mitochondrial stress signaling and unfolded protein response
  • Module 3: Neuroendocrine factors
  • Module 4: Neurotransmitters
  • Module 5: Hypoxia, sauna, and cold exposure
  • Module 6: Diaphragmatic breathing
  • Module 7: UV light
  • Module 8: Blue light
  • Module 9: Red and near-infrared light
  • Module 10: Biological clocks and chronobiology
  • Module 11: Circadian biology
  • Module 12: Sleep
  • Module 13: Disease Spotlight
    1. Rethinking Bipolar Disorder Beyond Conventional Understanding
    2. Rethinking Depressive Disorder Beyond Conventional Understanding

  • Module 1: The exposome
  • Module 2: Environmental toxins
  • Module 3: Clinical presentation of chronic toxicity
  • Module 4: Lab testing and interpretation for toxic load
  • Module 5: Detoxification processes (Phase I, II, and III)
  • Module 6: Impact of environmental exposures on epigenetics and disease susceptibility
  • Module 7: Personalized environmental health strategies
  • Module 8: Xenobiotics, toxins, and endocrine-disrupting chemicals
  • Module 9: Peroxisomes
  • Module 10: Psycho-social health
  • Module 11: Community, relationships, and living environment

Total Value: $5,320

Join Today For Only $470

Join before the deadline and save 91% off the regular a la carte price! 

About Your Instructor

Andrew Reid

Founder of Medgeeks

Here is a brief overview of my educational background:

  • Bachelor’s in Biology, California State University Dominguez Hills, 2010
  • Physician Assistant Program, University of California Davis, 2012
  • Master’s in Physician Assistant Studies, AT Still University, 2013
  • Master’s in Personalized Nutrition, University of Connecticut, 2025
  • Didactic Program in Dietetics, California State University Los Angeles, 2026 (currently enrolled)

I founded Medgeeks in 2012 to help clinicians excel in exams, rotations, and board preparation. Over time, this mission expanded into supporting practicing clinicians in primary care. As my perspective on health and disease evolved, so has my career path. I am entering a new phase in my professional career, where I want to redefine what it truly means to be healthy.

I want to highlight the complex biochemical mechanisms underlying disease to empower clinicians to practice personalized medicine. My daughter’s experience demonstrated how our current reductionist approach to medicine can fail in the face of chronic disease. There was a time when I thought I might lose her. But after learning how to identify and address the root cause of her condition—rather than mindlessly following established guidelines—I no longer have those thoughts. Today, she is healthy, growing, and thriving!

I’m thankful I never settled for the “next best step.” I questioned the system, challenged the status quo, and refused to let my daughter become another statistic. Had I followed the algorithm without question, our story would have turned out very differently.

The same philosophy and strategies that transformed my daughter’s health form the foundation of this new program. With this redefined view of health and disease, I’ve witnessed outcomes deemed “statistically impossible” by modern medicine. If we can accomplish this radical shift in health despite the complexity of her situation, then it can work for the majority.

Every day, I’m grateful for the opportunity to do meaningful work. I’m also thankful for the resources that allowed me to guide my daughter from a rare disease diagnosis to a vibrant, thriving toddler. Helping her conquer significant health challenges has been the most profound experience of my life. This experience forced me to learn in ways I had never been taught, served as the catalyst for change, and forged the path I will follow for the rest of my life.

To illustrate just how intricate—and interconnected—her condition was, here is a summary of the specific dysfunctions we identified and addressed:

  • Primary mitochondrial disease: m.3243A >G mutation in the MT-TL1 gene with a 90% heteroplasmy.

  • Methylcrotonyl-coa carboxylase 2 deficiency (leucine metabolism)

  • MTHFR C677T homozygous mutation (folate metabolism)

  • Thrombocytopenia (platelets of 2,000 per µL)

  • Iron deficiency (ferritin of 10 ng/mL)

  • Failure to thrive (1% for weight for her age)

  • Suppressed appetite

  • Muscle weakness (gross motor development impacted)

  • Hyperlipidemia

  • Elevated lactic acid

  • Elevated CPK

  • Elevated growth differential factor 15 (GDF-15)

  • Oculogyric crisis/paroxysmal tonic upgaze

  • Vertical and horizontal nystagmus

  • Ataxia

  • Absence seizures

  • Acute dystonic reactions

  • Mood dysregulation

  • Insomnia (delayed sleep onset and decreased sleep duration)

  • Chronic idiopathic urticaria

  • Photosensitivity

  • Recurrent oral ulcers

  • Elevated ANA

  • Elevated double-stranded DNA antibodies (IgG)

  • Elevated B2 Glycoprotein-1 antibodies (IgG)

  • Elevated cardiolipin antibodies (IgM)

  • Elevated histone antibodies

  • Low C3 complement

  • Low AH50 (alternative complement pathway)

  • Elevated IL-2 receptor

  • Elevated fecal calprotectin

Exclusive Early-Bird Offer

  • Join today and receive a 91% discount. You’ll get complimentary access to all seven courses at no additional charge. This is our way of expressing gratitude for your early support. 
  • Join today and receive lifetime, complimentary access to all our previously existing courses—free access to 700+ hours of clinical medicine lectures (video, audio, notes, and slides) valued at $10,175.

Your enrollment window, early-bird discount, and free bonuses end on April 6, 2025!

As always, you’ll be covered by our 30-day money-back guarantee.

Secure your spot below.

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